[Squamous cell carcinoma and basal cell carcinoma]

Area of Science:

• Dermatology
• Oncology
• Surgical Oncology

Context:

• Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are common skin malignancies.
• Early-stage BCC and SCC are typically treated with surgery.
• Advanced stages may require additional therapies like flap reconstruction, reduction surgery, or radiation.

Purpose:

• To evaluate the clinical efficacy of C' A' chemotherapy (CDDP, ADM or CBDCA, EPI-ADM) in advanced (Stage III and IV) non-melanoma skin cancers.
• To assess treatment response rates for both squamous cell carcinoma and basal cell carcinoma.

Summary:

• The C' A' chemotherapy regimen demonstrated a 63% response rate in Stage III and IV squamous cell carcinoma.
• The same regimen achieved a 75% response rate in Stage III and IV basal cell carcinoma.
• Chemotherapy offers a viable treatment option for advanced skin cancers, complementing surgical and radiation approaches.

Impact:

• Provides evidence for the effectiveness of C' A' chemotherapy in managing advanced BCC and SCC.
• Suggests chemotherapy as a valuable component in combination therapy for elderly patients with advanced skin cancers.
• Highlights the potential for improved patient outcomes in advanced non-melanoma skin cancer treatment.