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Related Experiment Videos

Spatial memory deficits in segmental trisomic Ts65Dn mice

G E Demas1, R J Nelson, B K Krueger

  • 1Department of Psychology, Johns Hopkins University, Baltimore, MD 21218, USA. demas@ren.psy.jhu.edu

Behavioural Brain Research
|December 1, 1996
PubMed
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Segmental trisomic 16 mice (Ts65Dn), a model for Down syndrome, exhibit significant short- and long-term spatial memory deficits. These memory impairments were observed using the 12-arm radial maze.

Area of Science:

  • Neuroscience
  • Genetics
  • Animal Models

Background:

  • Down syndrome (DS) is associated with cognitive deficits, including spatial memory impairments.
  • The segmental trisomic 16 mouse (Ts65Dn) is a widely used genetic model for DS, carrying a triplication of mouse chromosome 16 syntenic to human chromosome 21.
  • Understanding spatial memory in Ts65Dn mice can provide insights into the neurobiological underpinnings of DS-related cognitive dysfunction.

Purpose of the Study:

  • To investigate spatial working and long-term memory in Ts65Dn mice.
  • To determine if observed memory deficits are attributable to response bias, perceptual discrimination, or anxiety.
  • To assess the utility of the Ts65Dn mouse as a model for studying spatial memory deficits in Down syndrome.

Main Methods:

Related Experiment Videos

  • Spatial memory was assessed using the 12-arm radial maze (RAM) over multiple daily trials.
  • Performance metrics included correct choices, total choices, and trial completion time.
  • Spontaneous alternation in a T-maze and elevated plus maze tests were used to evaluate simple spatial memory and anxiety levels, respectively.

    • Main Results:

    • Ts65Dn mice demonstrated deficits in spatial working memory, performing at chance levels in the RAM.
    • Long-term memory was also impaired, as evidenced by performance decay after a 50-day retention period.
    • No significant differences in response bias, perceptual discrimination, or anxiety levels were found between Ts65Dn and control mice.

    Conclusions:

    • Ts65Dn mice exhibit significant short- and long-term spatial memory deficits.
    • These deficits are specific to spatial memory and not due to general cognitive impairment, anxiety, or sensory processing issues.
    • The Ts65Dn mouse model effectively replicates key spatial memory impairments observed in Down syndrome.