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Effects of arenastatin A and its synthetic analogs on microtubule assembly
Y Koiso1, K Morita, M Kobayashi
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Chemico-Biological Interactions
|December 20, 1996
Abstract:
Inhibition of microtubule assembly by arenastatin A (1) and five synthetic analogs (3-7) was examined. Arenastatin A and the triamide 6 showed potent and moderately strong inhibitory activities, respectively (IC50; 2.3 microM for 1, 7.8 microM for 6) and also depolymerized preformed microtubules. The other analogs tested showed no activity.