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Multicystic kidney in siblings
M S Moazin1, S Ahmed, K Fouda-Neel
1Department of Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Insights
This study reports on two siblings with multicystic kidney disease, a rare congenital kidney abnormality. Early surgical intervention led to positive outcomes, suggesting a potential genetic link for this condition.
Area of Science:
- Pediatric Nephrology
- Medical Genetics
Background:
- Multicystic kidney disease (MCKD) is typically considered a sporadic congenital renal abnormality.
- Prenatal diagnosis of renal abnormalities is increasingly common.
Observation:
- Two siblings, a male and a female, presented with left multicystic kidneys identified prenatally.
- Both siblings had a large renal mass; the second sibling also exhibited hypertension.
Findings:
- Surgical resection of the renal mass was performed early in both cases.
- Patients showed satisfactory clinical progress post-surgery, with hypertension resolving in the affected sibling.
Implications:
- These familial cases, alongside existing literature, suggest a possible genetic etiology for multicystic kidney disease.
- Further research into the genetic basis of MCKD may be warranted.
Abstract:
Two siblings (one girl and one boy), with a left multicystic kidney in whom a renal abnormality had been recognized prenatally, are reported. A large renal mass was present in both patients and the second sibling also had hypertension. Early surgical resection was carried out with satisfactory clinical progress and resolution of the hypertension. Multicystic kidney is considered a developmental abnormality with a sporadic incidence. These cases and other reports of familial incidence in the literature indicate that there may also be a genetic basis for the abnormality.