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Myocardial infarction, hyperthyroidism and normal coronary arteries: report of two cases
Canadian Medical Association Journal
|September 3, 1977
Insights
Myocardial infarction is rare in hyperthyroidism and without coronary artery disease. This study investigated two young, thyrotoxic men who experienced myocardial infarction despite clear coronary arteries.
Area of Science:
- Cardiology
- Endocrinology
Background:
- Myocardial infarction (MI) is typically associated with coronary artery disease.
- Hyperthyroidism is considered a less common cause of MI.
Observation:
- Two 33-year-old men presented with symptoms suggestive of myocardial infarction.
- Both patients were diagnosed with thyrotoxicosis (hyperthyroidism).
Findings:
- Cardiac catheterization and coronary angiography revealed no significant coronary artery abnormalities in either patient.
- This suggests MI can occur in hyperthyroidism without underlying coronary atherosclerosis.
Implications:
- Hyperthyroidism may play a more direct role in causing myocardial infarction than previously recognized.
- Further research is needed to elucidate the mechanisms linking thyrotoxicosis and MI in the absence of coronary artery disease.
Abstract:
Myocardial infarction is uncommon in persons with hyperthyroidism and also uncommon in the absence of demonstrable coronary artery disease. Cardiac catheterization and selective coronary angiography were performed in two men following apparent myocardial infarctions. Both patients were 33 years of age, thyrotoxic and angiographically free of coronary artery abnormalities.