Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human uteroglobin gene: structure, subchromosomal localization, and polymorphism

Z Zhang1, D B Zimonjic, N C Popescu

  • 1Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892, USA.

DNA and Cell Biology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Did Edgar Degas have Stargardt disease?

Ophthalmic genetics·2021
Same author

Effect of pill mill laws on opioid overdose deaths in Ohio & Tennessee: A mixed-methods case study.

Preventive medicine·2019
Same author

Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing.

Experimental eye research·2019
Same author

A novel mutation (LEU396ARG) in OPA1 is associated with a severe phenotype in a large dominant optic atrophy pedigree.

Eye (London, England)·2018
Same author

MRI Brain Volume Measurements in Infantile Neuronal Ceroid Lipofuscinosis.

AJNR. American journal of neuroradiology·2016
Same author

Structural and molecular changes in the aging choroid: implications for age-related macular degeneration.

Eye (London, England)·2016

The human uteroglobin (hUG) gene, located on chromosome 11, was studied for its role in atopic asthma and Best

Area of Science:

  • Genomics
  • Molecular Biology
  • Human Genetics

Background:

  • Human uteroglobin (hUG), also known as Clara cell 10-kD protein, is a secreted protein with immunomodulatory functions.
  • The hUG gene structure is conserved across vertebrates and located on human chromosome 11q12.3-13.1.
  • This chromosomal region is associated with candidate genes for diseases like atopic asthma and Best's vitelliform macular dystrophy.

Purpose of the Study:

  • To investigate the potential involvement of hUG gene mutations in the pathogenesis of atopic asthma and Best's disease.
  • To analyze the hUG gene sequence in patients with atopy or Best's disease.

Main Methods:

  • Gene sequencing of the hUG gene in patient cohorts.
  • Linkage analysis to determine gene proximity on chromosome 11.

Related Experiment Videos

Main Results:

  • A single base-pair change was identified in the hUG gene of Best's disease patients and controls, suggesting a polymorphism.
  • No causative mutations were found in the hUG gene for atopic asthma or Best's disease.

Conclusions:

  • The hUG gene does not appear to harbor mutations directly causing atopic asthma or Best's disease.
  • The conserved nature of the hUG gene highlights its physiological importance.
  • The hUG gene serves as a valuable chromosomal marker for identifying and characterizing nearby disease-related genes.