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Related Experiment Videos

STAT signaling is active during early mammalian development

S A Duncan1, Z Zhong, Z Wen

  • 1Department of Molecular Cell Biology, Rockefeller University, New York, New York 10021, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|February 1, 1997
PubMed
Summary

Signal transducer and activator of transcription (STAT) signaling is active during early mouse development. Activated STAT3 in maternal and extraembryonic tissues suggests its crucial role in embryogenesis.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Cytokines regulate gene expression via signal transducer and activator of transcription (STAT) pathways.
  • Cytokines play vital roles in early development, but STAT pathway activity during this period is not well understood.

Purpose of the Study:

  • To investigate STAT signaling pathway activity during early postimplantation stages of murine development.
  • To determine if STAT signaling contributes to developmental processes in early embryogenesis.

Main Methods:

  • Analysis of Stat1 and Stat3 mRNA presence in maternal and extraembryonic tissues.
  • Electrophoretic mobility shift assay (EMSA) to detect STAT protein activity in decidual swellings (E4.5-E9.5).

Main Results:

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  • Stat1 and Stat3 mRNAs were detected in maternal and extraembryonic tissues during early development.
  • Electrophoretic mobility shift assay confirmed active Stat3 protein during the E4.5-E9.5 developmental period.

Conclusions:

  • STAT signaling, specifically involving Stat3, is active during early postimplantation development in mice.
  • The presence of activated Stat3 indicates a significant role for STAT signaling in early embryogenesis and developmental processes.