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Published on: April 2, 2017
Induction of peroxisomal enzymes in rat liver by dehydroepiandrosterone sulfate
1Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Abstract:
Male F-344 rats, when treated with either 150 mg/kg or 300 mg/kg body weight of DHEAS for 14 days, produced a dose-dependent increase in liver weight and peroxisomal beta-oxidation activity, characteristic of peroxisomal proliferation. Contrary to previous observations in vitro, we also found a significant increase in catalase activity in rat liver with the higher dose of the steroid. Furthermore, the in vivo induction of peroxisomal beta-oxidation by DHEAS observed in our study was significantly less than reported in vitro, and also unlike previously reported in vitro results, was approximately equivalent to DHEA administered in vivo.
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