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Prolactin disorders

R A Yazigi¹, C H Quintero, W A Salameh

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

Fertility and Sterility

|February 1, 1997

Summary

Disorders of prolactin (PRL) production are common and can cause infertility, menstrual issues, and galactorrhea in women. Understanding pathophysiology aids successful clinical management of these conditions.

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Area of Science:

Endocrinology
Reproductive Medicine

Background:

Disorders of prolactin (PRL) production are prevalent in clinical practice.
These conditions can manifest with significant reproductive and endocrine disturbances.

Purpose of the Study:

To comprehensively review the pathophysiology, clinical features, diagnostic methods, and treatment strategies for PRL production disorders.
To provide practical guidance for clinicians managing common clinical challenges associated with these disorders.

Main Methods:

Extensive literature search of basic science and medical articles from the past 30 years using MEDLINE.
Review of recent endocrine and reproductive endocrine textbooks.
Selection of studies based on scientific contribution, study design, and content quality for critical evaluation and synthesis.

Main Results:

Abnormal PRL production disorders are frequently encountered.
Common clinical manifestations in women include infertility, menstrual irregularities, and galactorrhea.
While often benign, these disorders can occasionally lead to severe health consequences.

Conclusions:

A thorough understanding of PRL physiology and pathophysiology is crucial.
Recognizing the diverse clinical presentations is key to successful diagnosis and management.
This knowledge empowers clinicians to effectively approach and treat patients with PRL disorders.

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