Related Experiment Video
Updated: Aug 19, 2026
A High-Throughput Method For Zebrafish Sperm Cryopreservation and In Vitro Fertilization
Published on: July 7, 2009
Effects of cancer on spermatozoa quality after cryopreservation: a 12-year experience
O F Padron1, R K Sharma, A J Thomas
1Department of Urology, Cleveland Clinic Foundation, Ohio 44195, USA.
Objective:
To determine whether type of cancer and response to treatment was related to prefreeze or post-thaw semen quality and to predict post-thaw sperm motility from prefreeze motility.
Design:
Retrospective study.
Setting:
Tertiary care institution.
Patient(S):
One hundred six cancer patients cryopreserving their semen specimens.
Intervention(S):
Computer-assisted semen analysis was performed before and after cryopreservation on each patient specimen.
Main Outcome Measure(S):
The relationship of sperm motility and motion characteristics to type of cancer and patient's response to treatment.
Result(S):
Prefreeze and post-thaw semen quality did not differ between patients presenting with testicular cancer and Hodgkin's disease. Patients with leukemia or advanced soft tissue cancer had a higher prefreeze and post-thaw motility and higher total and motile sperm count than testicular and Hodgkin's disease patients. A prefreeze sperm motility of > or = 15% could predict a post-thaw motility of > 10%.
Conclusion(S):
Prefreeze or post-thaw semen quality in cancer patients is not affected (except the prefreeze motile sperm count within the testicular cancer patients) by the type of disease. Prefreeze motility can predict post-thaw motility. Cryopreservation of semen should be offered to cancer patients irrespective of the type of disease.
Related Concept Videos
01:41Spermatogenesis
01:23Infertility in Males