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Comparison of the CytoRich system with conventional cervical cytology. Preliminary data on 2,032 cases from a
1Department of Pathology, Creighton University School of Medicine, Omaha, Nebraska, USA.
Objective:
To compare the CytoRich system with conventional cervical cytology in a university medical center hospital laboratory.
Study Design:
The CytoRich system combines liquid preservation, selective reduction of blood/inflammation, thin-layer preparation and discrete staining. Two thousand thirty-two parallel conventional and CytoRich samples were examined as part of a multicenter trial of the CytoRich/AutoCyte systems. Same-patient conventional and CytoRich slides were submitted to separate cytotechnologists blindly. The results were compared, and all nonmatching sample pairs were reviewed again. A consensus diagnosis was derived for all cases. The initial readings of the CytoRich and conventional smears were compared with each other and with the consensus diagnosis.
Results:
Of the 148 squamous intraepithelial lesions (SILs) found by either method, 85% were found by CytoRich, while only 58.5% were found by conventional smear. As compared with the consensus diagnosis, CytoRich slides had 86.7% sensitivity for SIL and 99.1% specificity, while the conventional slides had 63.6% sensitivity and 99.7% specificity. Consensus review resulted in upgrading to SIL in 1.8% of conventional slides and 1.4% of CytoRich slides. The biopsy correlation results were similar for the two methods.
Conclusion:
The CytoRich system affords excellent cellular presentations and superior sensitivity for SILs when compared to the conventional technique.