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Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform
Published on: November 10, 2016
Optical tweezers-based immunosensor detects femtomolar concentrations of antigens
K Helmerson1, R Kishore, W D Phillips
1Atomic Physics Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Clinical Chemistry
|February 1, 1997
Abstract:
We used optical tweezers (optical trapping technology) to measure the force required to separate antigen-antibody bonds. Under competitive-binding conditions, we used the force determination to detect and measure protein antigen concentrations as small as 1 fmol/L (10(-15) mol/L).
