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Prenatal development of calbindin D-28K in human visual cortex
1Department of Anatomy and Neurobiology, Hunan Medical University, Changsha, Hunan, People's Republic of China.
Cerebral Cortex (New York, N.Y. : 1991)
|January 1, 1997
Summary
Calbindin D-28K (CB) expression in the human fetal visual cortex shows transient patterns before full development. This calcium-binding protein appears early and changes distribution as the cortex matures.
Area of Science:
- Neuroscience
- Developmental Biology
- Neuroanatomy
Background:
- Calbindin D-28K (CB) is a calcium-binding protein.
- Its role and distribution during human cortical development are not fully understood.
Purpose of the Study:
- To investigate the spatiotemporal distribution of CB in the human fetal primary visual cortex.
- To understand the developmental timeline and transient expression of CB.
Main Methods:
- Immunohistochemical analysis of human fetal brain tissue.
- Microscopic examination of CB distribution across cortical layers and developmental stages.
Main Results:
- CB is detected early in Cajal-Retzius cells and sparse neurons in ventricular/intermediate zones by 15 weeks gestation.
- CB expression emerges in deeper cortical layers (II-VI) from 26 weeks, progressing in an inside-out manner.
- CB labeling patterns shift, with transient expression in some layers and distinct localization in primary visual cortex by term.
Conclusions:
- CB expression is precocious, preceding complete laminar differentiation of the visual cortex.
- Some CB expression patterns are transient, highlighting dynamic developmental processes.
- CB distribution provides insights into the maturation of the human fetal visual cortex.