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Bactericidal activity, post antibiotic effect and modified controlled effective regrowth time of meropenem at high
K E Bowker1, H A Holt, D S Reeves
1Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust, UK. lesassays@ukneqasaa.win-uk.net
The Journal of Antimicrobial Chemotherapy
|December 1, 1996
Abstract:
The effect of increasing meropenem concentrations up to 250 mg/L, as might occur if 3 g was given as a single daily intravenous dose, was investigated in terms of bactericidal activity, post antibiotic effect (PAE) and modified controlled effective regrowth time (mCERT). Increasing the meropenem concentration above 50 mg/L did not result in increased bacterial killing, while concentrations over 75 mg/L did not result in longer PAE or mCERT.