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The decrease of maximal oxygen consumption during hypoxia in man: a mirror image of the oxygen equilibrium curve

G Ferretti1, C Moia, J M Thomet

  • 1Département de Physiologie, Centre, Médical Universitaire, Genève, Switzerland. ferretti@cmu.unige.ch

The Journal of Physiology
|January 1, 1997
PubMed
Summary

Endurance athletes experience reduced arterial oxygen saturation during maximal exercise, which is linked to their maximal oxygen consumption. This relationship is influenced by the oxygen equilibrium curve and differs between athletes and sedentary individuals.

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Area of Science:

  • Exercise Physiology
  • Respiratory Physiology
  • Sports Science

Background:

  • Endurance athletes exhibit significant reductions in arterial oxygen saturation (Sa,O2) during maximal exercise in normoxia.
  • This phenomenon is mitigated by breathing hyperoxic mixtures.
  • Maximal oxygen consumption (VO2,max) reduction in hypoxia correlates positively with individual normoxic VO2,max.

Purpose of the Study:

  • To test the hypotheses that the relationship between VO2,max and inspired partial pressure of oxygen (PI,O2) is determined by the oxygen equilibrium curve's shape.
  • To investigate if differences in this relationship between endurance athletes (E) and sedentary subjects (S) are due to their operating positions on the oxygen equilibrium curve.

Main Methods:

  • Compared VO2,max and Sa,O2 versus PI,O2 relationships in five sedentary and five endurance-trained subjects.

Related Experiment Videos

  • Measured VO2,max during cycloergometric exercise and Sa,O2 using infrared oximetry.
  • Analyzed blood gases (Pa,O2, Pa,CO2) and varied fraction of inspired oxygen (FI,O2) from 0.11 to 0.30.

    • Main Results:

    • The relationships between Sa,O2 or normalized VO2,max and FI,O2 exhibited similar shapes.
    • Data for endurance athletes were consistently lower and significantly different from sedentary subjects.
    • Found statistically equivalent linear relationships between Sa,O2 and normalized VO2,max for both groups.

    Conclusions:

    • The relationships between VO2,max or Sa,O2 and inspired oxygen levels are mirror images.
    • This implies a strong link between VO2,max decrease in hypoxia and the oxygen equilibrium curve's shape.
    • Differences between athletes and sedentary individuals are explained by their positions on the oxygen equilibrium curve.