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Related Experiment Videos

Moclobemide versus fluoxetine for double depression: a randomized double-blind study

A Duarte1, H Mikkelsen, A Delini-Stula

  • 1Mental Health Department, British Hospital, School of Medicine, University of Buenos Aires, Argentina.

Journal of Psychiatric Research
|November 1, 1996
PubMed
Summary

Moclobemide and fluoxetine showed similar tolerability for double depression treatment. Moclobemide demonstrated higher efficacy, with 71% of patients achieving significant symptom reduction compared to 38% on fluoxetine.

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Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Double depression, characterized by dysthymia with superimposed major depressive episodes, presents a complex treatment challenge.
  • Selective reversible monoamine oxidase A inhibitors and selective serotonin uptake inhibitors are common pharmacological approaches.

Purpose of the Study:

  • To compare the efficacy and tolerability of moclobemide and fluoxetine in patients with double depression.
  • To evaluate treatment outcomes using standardized depression rating scales.

Main Methods:

  • A six-week, single-center, double-blind, fixed-dose study.
  • Involved 42 patients diagnosed with double depression (DSM-III-R).
  • Weekly assessments included the Hamilton Depression Rating Scale (HDRS-17) and Clinical Global Impression (CGI) scale.

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Main Results:

  • More patients achieved a >= 50% decrease in HDRS score with moclobemide (71%) compared to fluoxetine (38%, p < 0.05).
  • No significant differences were observed in secondary efficacy measures.
  • Moclobemide was associated with only mild transient anxiety in one patient; both drugs were well-tolerated.

Conclusions:

  • Moclobemide and fluoxetine appear equally well-tolerated and similarly effective in treating double depression.
  • Moclobemide may offer superior efficacy, warranting further investigation in larger, placebo-controlled trials.