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Sudden unexplained death in epilepsy: observations from a large clinical development program

J E Leestma1, J F Annegers, M J Brodie

  • 1Chicago Institute of Neurosurgery and Neuroresearch, Illinois, USA.

Epilepsia
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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The rate of sudden unexplained death in epilepsy (SUDEP) among patients in lamotrigine clinical trials was 3.5 per 1,000 patient-years. This SUDEP rate is comparable to expected rates in high-risk epilepsy populations.

Area of Science:

  • Neurology
  • Epileptology
  • Clinical Pharmacology

Background:

  • Sudden unexplained death in epilepsy (SUDEP) is a critical concern in epilepsy management.
  • Understanding SUDEP rates in specific patient populations and drug development programs is essential for risk assessment.

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