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Updated: Jul 22, 2026

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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Genetic irony beyond haemochromatosis: clinical effects of HLA-H mutations
1Department of Molecular and Experimental Medicine, Scripps Research, Institute, La Jolla, CA 92037, USA.
Lancet (London, England)
|February 1, 1997
Abstract
No abstract available in PubMed .
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Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
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