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Acute lymphoblastic leukemia presenting with typhlitis

S C Kaste1, P M Flynn, W L Furman

  • 1Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.

Medical and Pediatric Oncology
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Acute lymphoblastic leukemia (ALL) can mimic typhlitis, causing right lower quadrant pain. This case highlights the importance of recognizing typhlitis symptoms and imaging findings, especially during leukemia treatment.

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Area of Science:

  • Oncology
  • Pediatric Hematology
  • Gastroenterology

Background:

  • Acute lymphoblastic leukemia (ALL) is a common childhood cancer.
  • Typhlitis, also known as neutropenic enterocolitis, is an inflammation of the intestines.
  • Right lower quadrant pain can have various differential diagnoses in adolescents.

Observation:

  • A 17-year-old boy presented with acute right lower quadrant pain.
  • Initial ultrasonography suggested typhlitis.
  • Symptoms resolved with antibiotics and conservative management.

Findings:

  • Typhlitis-like symptoms recurred in the patient after initiating chemotherapy for ALL.
  • This recurrence suggests a complex interplay between leukemia, its treatment, and gastrointestinal complications.
  • The case underscores the need for vigilance in diagnosing and managing gastrointestinal issues during ALL therapy.

Implications:

  • Accurate diagnosis of typhlitis in ALL patients is crucial for appropriate management.
  • Clinicians should consider typhlitis in the differential diagnosis of abdominal pain in ALL patients, particularly during chemotherapy.
  • Understanding this presentation can improve patient outcomes and treatment strategies for pediatric leukemia.