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DCC's function takes shape in the nervous system
1823 Light Hall, Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232-0295, USA. kolodzp@ctrvax. vanderbilt.edu
Current Opinion in Genetics & Development
|February 1, 1997
Abstract:
Deleted in colorectal cancer (DCC), a candidate tumor-suppressor gene, has recently been found to encode a netrin receptor required for axon guidance in vitro. Mutations in Caenorhabditis elegans and Drosophila genes encoding DCC-related proteins affect axon guidance, and these phenotypes resemble those of mutations in netrin genes. Netrins and their DCC-related receptors thus play an evolutionarily conserved role in midline guidance, and DCC may be required more generally for cellular morphogenesis.