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Related Experiment Videos

DCC's function takes shape in the nervous system

P A Kolodziej1

  • 1823 Light Hall, Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232-0295, USA. kolodzp@ctrvax. vanderbilt.edu

Current Opinion in Genetics & Development
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

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Deleted in colorectal cancer (DCC) acts as a netrin receptor crucial for axon guidance. This gene

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The Deleted in colorectal cancer (DCC) gene is a candidate tumor suppressor.
  • DCC encodes a receptor for netrins, molecules involved in axon guidance.

Purpose of the Study:

  • To investigate the role of DCC in axon guidance and cellular morphogenesis.
  • To explore the evolutionary conservation of DCC and netrin interactions.

Main Methods:

  • Analysis of mutations in DCC and related genes in model organisms.
  • In vitro studies of DCC's function in axon guidance.

Main Results:

  • DCC is essential for axon guidance in vitro.
  • Mutations in DCC-related genes in C. elegans and Drosophila disrupt axon guidance.

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  • Phenotypes observed in these mutations resemble those of netrin gene mutations.

    • Conclusions:

    • DCC and netrins play a conserved role in midline guidance across species.
    • DCC may have broader functions in cellular morphogenesis beyond axon guidance.