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Crystal structure of the Src family tyrosine kinase Hck
F Sicheri1, I Moarefi, J Kuriyan
1Laboratories of Molecular Biophysics, The Rockefeller University, New York 10021, USA.
Nature
|February 13, 1997
Abstract:
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.