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Eprinomectin: a novel avermectin for use as a topical endectocide for cattle
W L Shoop1, J R Egerton, C H Eary
1Merck Research Laboratories, Rahway, NJ 07065-0900, USA.
International Journal for Parasitology
|November 1, 1996
Summary
Eprinomectin, a novel topical endectocide, demonstrates high efficacy against internal and external parasites in cattle. This broad-spectrum treatment is safe for all cattle, including dairy cows, with no observed adverse reactions.
Area of Science:
- Veterinary Parasitology
- Pharmacology
Background:
- Eprinomectin is a novel avermectin developed for topical endectocide use in cattle.
- Its efficacy against a wide range of internal and external parasites needs thorough evaluation.
Purpose of the Study:
- To assess the anthelmintic, insecticidal, and miticidal activity of topically applied eprinomectin in cattle.
- To determine the safety and efficacy of eprinomectin for all cattle types, including lactating dairy cows.
Main Methods:
- Eprinomectin was applied topically to cattle at various dosages (0.08 to 0.5 mg/kg).
- Experimental infections with gastrointestinal nematodes and natural infestations with lice, horn flies, and mange mites were used.
- Efficacy was evaluated against adult and immature parasite stages, as well as ectoparasites.
Main Results:
- Eprinomectin achieved >98% efficacy against most adult and immature gastrointestinal nematodes at 0.2 and 0.5 mg/kg.
- Complete elimination of lice was observed by day 14 at all tested dosages.
- High efficacy (>94%) against horn flies and mange mites was maintained for up to 6 weeks.
Conclusions:
- Eprinomectin exhibits excellent broad-spectrum endectocidal activity against key cattle parasites.
- Topical administration of eprinomectin is a safe and effective method for parasite control in all cattle populations.