Intramitochondrial calcification and myocardial inclusions in the rabbit due to anoxic hypoxia

Intramitochondrial calcium granules and calcification of the mitochondrial cristae were examined in myocardial cells of rabbits in acute anoxic hypoxia, under normal circulation. The alterations were noted first after 2 hours of hypoxia, and became progressively larger and more ubiquitous with increasing periods of anoxic hypoxia. After 8 hours or longer hypoxia intramitochondrial "cristalloids" were found in some mitochondria.