Related Experiment Video

Updated: Oct 3, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Correlation of lipoprotein (a) to angiographically defined coronary artery disease in Indians

R Gupta1, S Vasisht, V K Bahl

  • 1Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

International Journal of Cardiology
|December 13, 1996
PubMed

Insights

Lipoprotein (a) [Lp(a)] is a better predictor of coronary artery disease (CAD) in Indian patients than traditional lipid markers. Higher Lp(a) levels significantly correlate with the presence and severity of angiographically defined CAD.

Area of Science:

  • Cardiology
  • Clinical Biochemistry
  • Preventive Medicine

Background:

  • Lipoprotein (a) [Lp(a)] levels are known to correlate with coronary artery disease (CAD).
  • Lp(a) distribution patterns vary across different racial groups.
  • Understanding Lp(a) in diverse populations like Indians is crucial for CAD risk assessment.

Purpose of the Study:

  • To investigate the relationship between Lp(a) levels and angiographically defined CAD in Indian patients.
  • To compare the predictive value of Lp(a) against traditional lipid profiles for CAD.
  • To assess the graded association between Lp(a) concentration and CAD severity.

Main Methods:

  • Plasma Lp(a) and lipid profiles were measured in 101 Indian patients undergoing coronary arteriography.
  • Patients were categorized into CAD and normal coronary artery groups.
  • Lp(a) and lipid levels were analyzed across different quartiles and compared between groups.

Main Results:

  • Lp(a) concentrations were significantly higher in patients with CAD compared to those without (26.83 vs. 15.07 mg/dl, P < 0.05).
  • A graded association was observed, with CAD prevalence increasing across Lp(a) quartiles, reaching 100% in the highest quartile (> or = 76 mg/dl).
  • Traditional lipid markers including total cholesterol, triglycerides, HDL, LDL, and their ratios did not show significant differences between CAD and normal groups, except for HDL which was not significantly different.

Conclusions:

  • Lp(a) measurement is a superior marker for predicting angiographically defined CAD in Indian patients compared to traditional lipid measures.
  • Elevated Lp(a) levels demonstrate a strong, graded association with the presence and severity of coronary artery disease.
  • Further research into Lp(a) 's role in cardiovascular risk stratification in diverse ethnic groups is warranted.

More Related Videos

Quantification of Atherosclerosis in Mice06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...