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Pentoxifylline inhibits tumor necrosis factor alpha-induced priming of human neutrophils
P T Paradowski1, K Zeman, R Pietruszyński
1Department of Orthopedics and Traumatology, Military School of Medicine, Lódź, Poland.
Immunology Letters
|November 1, 1996
Abstract:
The study was designed to study the effect of pentoxifylline PTX on the chemiluminescence responses of neutrophils and on tumor necrosis factor-alpha (TNF-alpha)-induced priming of neutrophils. The results demonstrate that TNF-alpha stimulated the respiratory burst by neutrophils and primed them for enhanced response to fMLP but not to PMA. The effect of TNF-alpha on the oxygen metabolism of neutrophils was inhibited when cells were treated with PTX. This reaction was dose-dependent. Additionally, the inhibiting influence of PTX on the chemiluminescence response of neutrophils was observed.