Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine receptors and brain function

M Jaber1, S W Robinson, C Missale

  • 1Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

Neuropharmacology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential effect of acute reserpine administration on D-1 and D-2 dopaminergic receptor density and function in rat striatum.

Neurochemistry international·2010
Same author

Gene expression profile of prostate cancer cell lines: effect of nerve growth factor treatment.

Molecular and cellular endocrinology·2008
Same author

Oligomeric assembly of dopamine D1 and glutamate NMDA receptors: molecular mechanisms and functional implications.

Biochemical Society transactions·2004
Same author

Sex-related variations in serum nerve growth factor concentration in humans.

Neuropeptides·2003
Same author

Retinoic acid prevents experimental Cushing syndrome.

The Journal of clinical investigation·2001
Same author

Genetic animal models: focus on schizophrenia.

Trends in neurosciences·2001
Same journal

Thyrotropin-releasing hormone and dopaminergic systems interact in the ventral tegmental area to regulate food intake in rats.

Neuropharmacology·2026
Same journal

TRPC5 as a modulator of TRPV1 signalling in pathological pain states.

Neuropharmacology·2026
Same journal

Loss of mGlu<sub>5</sub> receptors from PV inhibitory neurons attenuates sex differences in ethanol and sucrose seeking.

Neuropharmacology·2026
Same journal

PM289, a synthetic CB2 in vitro receptor agonist, modulates morphine-induced antinociceptive effect and withdrawal syndrome in an animal model of osteoarthritic pain.

Neuropharmacology·2026
Same journal

Purinergic-cytokine signaling as a regulatory axis in neuroimmune development.

Neuropharmacology·2026
Same journal

Acupuncture improves depressive symptoms and prefrontal cortical function in mild to moderate depressive disorder: A randomized sham-controlled trial and fNIRS study.

Neuropharmacology·2026
See all related articles

Dopamine receptors in the central nervous system (CNS) control movement, cognition, and hormone secretion. New research on D3 and D4 receptors offers hope for improved antipsychotic medications with fewer side effects.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • Dopamine receptors (DRs) are G-protein coupled receptors crucial for CNS functions.
  • DRs are classified into D1-like (Gs-coupled) and D2-like (Gj-coupled) subclasses.
  • Specific DR subtypes exhibit distinct anatomical distributions and neuronal expression patterns.

Purpose of the Study:

  • To review the roles of dopamine receptor subtypes in the CNS.
  • To explore the potential of D3 and D4 receptors in treating psychiatric disorders.
  • To highlight the utility of genetically modified animals in understanding DR function.

Main Methods:

  • Review of existing literature on dopamine receptor subtypes.
  • Analysis of receptor distribution and signaling pathways.

Related Experiment Videos

  • Consideration of findings from genetically engineered animal models.

    • Main Results:

    • Dopamine regulates locomotion, cognition, affect, and prolactin secretion via DRs.
    • D1 and D2 receptors are abundant and often expressed in distinct neuronal populations.
    • D3 and D4 receptors are implicated in cognition and affect, and may be targets for novel neuroleptics.

    Conclusions:

    • Dopamine receptor subtypes play diverse roles in CNS physiology.
    • Targeting D3 and D4 receptors may lead to more effective treatments for schizophrenia with reduced side effects.
    • Genetically modified animal models are essential for elucidating specific receptor functions.