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Updated: Aug 16, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
A QSAR study of the antimalarial activity of some synthetic 1,2,4-trioxanes
M Grigorov1, J Weber, J M Tronchet
1Department of Physical, University of Geneva, Switzerland.
Journal of Chemical Information and Computer Sciences
|January 1, 1997
Abstract:
The antimalarial activity of a series of synthetic 1,2,4-trioxanes is correlated with molecular structure by using a pharmacophore search method (CATALYST). The technique is shown to have predictive accuracy and confirms that docking between an active trioxane and the receptor, heme, is the crucial step for drug action.
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