Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Factor XIII deficiency in burns]

H Burkhardt, P R Zellner, I Möller

    Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Erratum: Balancing conservation and human access to nature: the impact of a constructed causeway on water levels and sedimentation, North Bull Island, Ireland - ERRATUM.

    Cambridge prisms. Coastal futures·2025
    Same author

    Balancing conservation and human access to nature: the impact of a constructed causeway on water levels and sedimentation, North Bull Island, Ireland.

    Cambridge prisms. Coastal futures·2025
    Same author

    Compartments of the crural fascia: clinically relevant ultrasound, anatomical and histological findings.

    Surgical and radiologic anatomy : SRA·2023
    Same author

    First Search for Exclusive Diphoton Production at High Mass with Tagged Protons in Proton-Proton Collisions at sqrt[s]=13  TeV.

    Physical review letters·2022
    Same author

    Odderon Exchange from Elastic Scattering Differences between pp and pp[over ¯] Data at 1.96 TeV and from pp Forward Scattering Measurements.

    Physical review letters·2021
    Same author

    Compartments of the antebrachial fascia of the forearm: clinically relevant ultrasound, anatomical and histological findings.

    Surgical and radiologic anatomy : SRA·2021
    Same journal

    [S3 Guideline "Adult soft tissue sarcomas"].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
    Same journal

    [Synopsis-S3 guidelines pancreatic cancer].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
    Same journal

    [Laparoscopic sentinel node navigation surgery in gastric cancer to reduce surgical radicality].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
    Same journal

    [Future concepts for neoadjuvant and adjuvant treatment of (resectable) pancreatic cancer].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
    Same journal

    [ASCO guidelines for the treatment of stage III NSCLC part 4: indications for adjuvant therapy].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
    Same journal

    [Surgical treatment of pancreatic cancer-What is new?]

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
    See all related articles

    Severe burn injuries significantly reduce factor XIII levels. Heparin treatment may help maintain higher factor XIII levels in burn patients, though platelet counts remained similar between groups.

    Area of Science:

    • Hematology
    • Burn Injury Research
    • Coagulation Science

    Context:

    • Severe burn injuries represent a significant clinical challenge, often leading to complex physiological responses.
    • Hemostasis, the process of stopping bleeding, is frequently disrupted in burn patients, impacting recovery and survival.
    • Understanding alterations in coagulation factors is crucial for managing burn trauma.

    Purpose:

    • To investigate the dynamic changes in key hemostasis parameters in patients with severe burn injuries.
    • To evaluate the effect of heparin administration on these hemostasis parameters.
    • To analyze the clinical significance of observed hemostatic alterations in burn patients.

    Summary:

    • Daily measurements of platelets, fibrinogen, prothrombin time, partial thromboplastin time, thrombin time, and factor XIII were conducted in 34 severe burn patients.

    Related Experiment Videos

  • A rapid decline in factor XIII to approximately 30% was observed within the first 4 days, persisting throughout the 20-day observation period.
  • Patients receiving heparin (15,000 IE/24h) exhibited 10-15% higher factor XIII levels compared to the control group, while platelet counts showed similar recovery patterns in both groups.

    • Impact:

    • Findings highlight a critical impairment of factor XIII in severe burn injuries, suggesting a potential role in hypercoagulability or impaired wound healing.
    • Heparin therapy may offer a protective effect on factor XIII levels, warranting further investigation into its therapeutic benefits in burn management.
    • This study underscores the importance of monitoring coagulation profiles in severe burn patients to guide clinical interventions and improve patient outcomes.