Concomitant administration of haloperidol and lithium carbonate in acute mania

Prospective and retrospective studies of 55 psychotic patients treated concomitantly with oral haloperidol and lithium carbonate did not reveal any evidence of permanent brain damage or persistent dyskinesias; adverse reactions were transient and without sequelae. Results in these patients afford further evidence that combined use of haloperidol and lithium is safe and effective in the treatment of mania. Careful management is essential to minimize the risk of serious adverse reaction.