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Maternal floor infarction in autoimmune disease: two cases
1Department of Pathology, Kosair Children's Hospital, Louisville, KY 40232-5070, USA.
Summary
Maternal floor infarction may be linked to autoimmune responses. Antibodies targeting the placental urokinase plasmin system might cause this condition in pregnant women.
Area of Science:
- Reproductive immunology
- Maternal-fetal medicine
Background:
- Maternal floor infarction (MFI) is a rare placental pathology.
- Autoimmune conditions can affect pregnancy outcomes.
Observation:
- Two cases of MFI in women producing antibodies to various antigens were studied.
- These women had autoimmune antibody production.
Findings:
- A potential link between MFI and autoimmune antibody production is suggested.
- Antibodies targeting the placental urokinase plasmin system are hypothesized as a cause for MFI.
Implications:
- This research may elucidate the pathogenesis of maternal floor infarction.
- Understanding the role of autoimmune antibodies could lead to new diagnostic or therapeutic strategies.