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Reference values for singleton and twin placental weights

H Pinar1, C J Sung, C E Oyer

  • 1Developmental Pathology Program, Women and Infants' Hospital of Rhode Island, Providence 02905, USA.

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
|November 1, 1996
PubMed
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Twin placentas show accelerated weight gain between 24-36 weeks, unlike uniform singleton placental weight gain. Modern placentas are heavier, suggesting generational or nutritional shifts.

Area of Science:

  • Obstetrics
  • Perinatology
  • Placental biology

Background:

  • Limited data exists for normal twin placental weights.
  • Previous studies, like the Collaborative Perinatal Study (1959-1966), focused on singleton placentas.
  • Understanding placental weight is crucial for assessing fetal growth and development.

Purpose of the Study:

  • To establish normal reference ranges for singleton and twin placental weights.
  • To compare the weight gain patterns of singleton and twin placentas throughout gestation.
  • To investigate potential changes in placental weight over time.

Main Methods:

  • Analysis of 787 singleton and 514 twin normal placentas.
  • Exclusion of placentas with conditions affecting weight.

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  • Comparison of current data with historical placental weight data.

    • Main Results:

    • Twin placental weight gain accelerates between 24 and 36 weeks, plateauing after 37 weeks.
    • Singleton placentas exhibit more uniform weight gain throughout gestation.
    • Mean twin placental weights are less than double singleton weights at the same gestational age.
    • Current singleton and twin placentas are heavier than historical data.

    Conclusions:

    • Placental weight gain patterns differ significantly between singleton and twin gestations.
    • Modern placentas appear heavier than those from previous decades, possibly due to generational or nutritional factors.
    • Updated reference ranges for placental weights are needed for accurate clinical assessment.