Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clear cell rhabdomyosarcoma

F Boman1, J Champigneulle, C Schmitt

  • 1Department of Pathology, Brabois Hospital, Vandoevre-Nancy, France.

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of the charge asymmetry in top quark pair production in <i>pp</i> collisions at [Formula: see text] using the ATLAS detector.

The European physical journal. C, Particles and fields·2015
Same author

Search for lepton flavour violation in the <i>eμ</i> continuum with the ATLAS detector in [Formula: see text]<i>pp</i> collisions at the LHC.

The European physical journal. C, Particles and fields·2015
Same author

Measurement of [Formula: see text] production with a veto on additional central jet activity in <i>pp</i> collisions at [Formula: see text] TeV using the ATLAS detector.

The European physical journal. C, Particles and fields·2015
Same author

Measurement of the top quark mass with the template method in the [Formula: see text] channel using ATLAS data.

The European physical journal. C, Particles and fields·2015
Same author

Search for heavy neutrinos and right-handed <i>W</i> bosons in events with two leptons and jets in <i>pp</i> collisions at [Formula: see text] with the ATLAS detector.

The European physical journal. C, Particles and fields·2015
Same author

Measurement of <i>τ</i> polarization in <i>W</i>→<i>τν</i> decays with the ATLAS detector in <i>pp</i> collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same journal

Cytogenetics of an atypical Spitz nevus metastatic to a single lymph node.

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association·1998
Same journal

Renal medullary carcinoma: a potential sickle cell nephropathy of children and adolescents.

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association·1998
Same journal

Amebic osteomyelitis in a child with acquired immunodeficiency syndrome: a case report.

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association·1998
Same journal

Child fatality associated with pathological features of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease).

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association·1998
Same journal

Atypical Pneumocystis carinii pneumonia in a child with hyper-IgM syndrome.

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association·1998
Same journal

Alterations of the enteric nervous system in neonatal necrotizing enterocolitis revealed by whole-mount immunohistochemistry.

Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association·1998
See all related articles

This study details a rare clear cell rhabdomyosarcoma in a child, characterized by extensive growth and muscle markers. Advanced microscopy confirmed glycogen accumulation and striated muscle features, aiding diagnosis.

Area of Science:

  • Oncology
  • Pathology
  • Pediatric Cancer Research

Background:

  • Clear cell rhabdomyosarcoma is a rare malignant tumor often affecting children.
  • Parapharyngeal masses can present diagnostic challenges, especially with intracranial extension.

Observation:

  • A large, painful left parapharyngeal mass with intracranial extension and cervical lymph node metastasis was observed in a 10-year-old boy.
  • Microscopic examination revealed a diffuse and focally alveolar architecture with three distinct cell types.
  • Clear cells with abundant vacuolated cytoplasm, cells with eosinophilic fibrillar cytoplasm, and smaller cells with a high nucleocytoplasmic ratio were identified.

Findings:

  • Periodic acid-Schiff staining demonstrated significant intracytoplasmic glycogen in clear cells.

Related Experiment Videos

  • Immunohistochemistry confirmed tumor cell expression of muscle markers: desmin, muscle actins, and dystrophin.
  • Electron microscopy revealed intracytoplasmic glycogen deposits, lipid droplets, and features of striated muscle differentiation.

    • Implications:

    • This case highlights the importance of comprehensive histopathological analysis for diagnosing rare pediatric tumors.
    • Understanding the ultrastructural and molecular features of clear cell rhabdomyosarcoma can guide treatment strategies.
    • Accurate diagnosis is crucial for appropriate management and prognosis in pediatric rhabdomyosarcoma cases.