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Chromogenic lactate-leukocyte esterase substrates
1Diagnostics Division, Bayer Corporation, Elkhart, Indiana 46515, USA.
Bioconjugate Chemistry
|January 1, 1997
Abstract:
The first successful reported use of lactate-based chromogenic, colorimetric substrates for a serine protease-based enzyme is described. A series of hydroxy-protected 5-phenyl-3-hydroxypyrrolyl L-lactate substrates of the general formula RO-Lac-OPP were prepared and formulated into reagents for the determination of leukocytes in dry phase formats.