[Biophysical models of the formation of radiation-induced chromosome aberrations]

The brief analysis of the development of biophysical models describing the formation of chromosome aberrations is given. It is shown that, though the target theory is obsolete and does not correspond to modern radiobiological knowledge, however hit and target principles are still the basic radiobiological concepts. Three main directions of the development of biophysical models are submitted; their shortcomings and possible ways of perfection of the models are specified.