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Related Experiment Videos

Alterations in intestinal function in acute pancreatitis in an experimental model

X D Wang1, Q Wang, R Andersson

  • 1Department of Surgery, Lund University Hospital, Sweden.

The British Journal of Surgery
|November 1, 1996
PubMed
Summary

Acute pancreatitis impairs intestinal barrier function and nutrient absorption. Hydroxyl radical scavengers partially protected against these gut issues, suggesting a role for free radicals in pancreatitis-induced gastrointestinal complications.

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Area of Science:

  • Gastroenterology
  • Pathophysiology
  • Sepsis Research

Background:

  • Gastrointestinal tract failure is a potential contributor to systemic septic complications in acute pancreatitis.
  • Early detection and understanding of gut dysfunction are crucial for managing acute pancreatitis.

Purpose of the Study:

  • To evaluate systemic and intestinal circulation, intestinal permeability, and absorptive function in the early stages of acute pancreatitis in rats.
  • To investigate the role of oxygen-derived free radicals in pancreatitis-induced gastrointestinal alterations.

Main Methods:

  • Acute pancreatitis was induced in rats using sodium taurodeoxycholate and trypsin.
  • Systemic and intestinal hemodynamics were monitored.
  • Intestinal permeability was assessed using radiolabeled albumin and small/macromolecular markers.

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  • Gut absorptive capacity was measured by D-xylose absorption.
  • The effect of dimethyl sulfoxide (a hydroxyl radical scavenger) was evaluated.

    • Main Results:

    • Acute pancreatitis led to decreased systemic arterial pressure and intestinal blood flow.
    • Intestinal permeability increased significantly in the distal ileum and colon.
    • Transport of small and macromolecular markers across the intestinal epithelium was altered.
    • D-xylose absorption was significantly reduced in pancreatitis.
    • Dimethyl sulfoxide administration ameliorated compromised intestinal permeability and absorptive capacity but did not impact hemodynamic changes.

    Conclusions:

    • Cytotoxic oxygen-derived free radicals likely contribute to the early-stage alterations in intestinal permeability and absorptive function observed in acute pancreatitis.
    • Targeting free radical damage may offer a therapeutic strategy for mitigating gastrointestinal dysfunction in acute pancreatitis.