An experimental permeabilization of the blood-brain barrier by electric field application

This work investigates the method of 'transcerebral electrolysis' in rabbits previously used by other authors (e.g. G. Bourguignon). The observation of the animal, with EEG record, and the macroscopic and microscopic studies, have allowed to precise the physical parameters which do not damage the brain functions: current intensity of not more than 5 mA, applied on large electrodes. In this manner, without traumatization of the brain, the blood-brain barrier allows passage of many substances (dyes, tracers, drugs) and this permeability remains for several days.