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[Sinus bradycardia secondary to systemic pentamidine]
M Izquierdo Patrón1, C Lafuente, M Haro Estarriol
1Sección de Neumología, Hospital General de Albacete.
Revista Espanola De Cardiologia
|December 1, 1996
Summary
Intravenous pentamidine can cause frequent, severe cardiac side effects. This report details the first case of sinus bradycardia, a slow heart rhythm, in a non-HIV-infected patient receiving this medication.
Area of Science:
- Pharmacology
- Cardiology
- Adverse Drug Reactions
Background:
- Parenteral pentamidine is frequently associated with systemic side effects.
- Cardiac conduction abnormalities, including tachyarrhythmias and prolonged QT intervals, are known adverse effects of intravenous pentamidine.
- Bradyarrhythmias are a rare complication, with only one prior report in an HIV-infected patient.
Observation:
- This case report describes a novel adverse effect of intravenous pentamidine therapy.
- The patient, who is not infected with HIV, developed sinus bradycardia during treatment.
Findings:
- Intravenous pentamidine administration led to the development of sinus bradycardia.
- This represents the first documented instance of sinus bradycardia associated with intravenous pentamidine in a non-HIV-infected individual.
Implications:
- Clinicians should be aware of the potential for intravenous pentamidine to induce sinus bradycardia, even in non-HIV-infected patients.
- This finding expands the known spectrum of cardiac adverse effects associated with pentamidine.
- Further monitoring for bradyarrhythmias may be warranted in patients receiving intravenous pentamidine.