[The optimization of the infusion therapy procedure in patients with acute leukemias]

In a trial of 202 patients with acute leukemia (AL) the authors studied the effect of volume and quality of infusion therapy (forced diuresis 2.5 l/m, parenteral nutrition, hemocomponent therapy) on early mortality, frequency of complications, complete remission, overall and relapse-free survival. It is shown that the response in remission induction depends on the scope and quality of infusion therapy. Balanced complete infusion therapy led to a complete remission in 75% and 92% of patients with acute nonlymphoblastic and acute lymphoblastic leukemia, respectively, compared to 29 and 50% for infusion-untreated patients. Early lethality was 6 and 0%, 42 and 18%, respectively. Higher efficacy of acute leukemia treatment in adjuvant balanced infusion therapy results from lower toxicity of chemotherapy and possible performance of induction therapy without reduction of drug doses.