[The characteristics of different types of mRNA expressed in the human brain]

Considerable decrease of expression of some "brain-specific" genes obtained in previous experiments was detected by means of differential hybridization of gridded human fetal brain cDNA library with total cDNA probes, synthetized on mRNAs isolated from the normal brain cells and several tumor cells. In contrast, for few genes expressed on low level in human fetal brain the evident increase of expression level in human brain tumour cells was found. The nucleotide sequences of some of these genes and previously isolated genes which have different specificity of expression were determined.