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[Differentiated carcinoma in autonomously functioning thyroid nodule: case report]

M Ducci1, M Appetecchia, A Marzetti

  • 1Divisione ORL e Chirurgia Cervico-Facciale, Instituto Regina Elena per lo studio e la cura dei tumori, Roma.

Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-Facciale
|June 1, 1996
PubMed
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This study details a rare case of a hyperfunctioning differentiated thyroid carcinoma in a young woman, presenting as an autonomously functioning thyroid nodule that was unresponsive to treatment. The findings highlight the unusual co-occurrence of hyperthyroidism, Hashimoto

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Autonomously functioning thyroid nodules can cause hyperthyroidism.
  • Thyroid cancer is rare in adolescents and young adults.
  • Hashimoto's thyroiditis is an autoimmune condition affecting the thyroid.

Observation:

  • A 13-year-old female presented with an autonomously functioning thyroid nodule.
  • Nine years later, she developed hyperthyroidism unresponsive to thyreostatic treatment.
  • Histological diagnosis revealed papillary carcinoma within the nodule, coexisting with Hashimoto's thyroiditis and lymph node metastasis.

Findings:

  • The autonomously functioning nodule was composed entirely of neoplastic tissue.
  • The remaining thyroid tissue showed no adenomatous changes.

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  • Failure of thyreostatic treatment suggested a neoplastic cause for hyperthyroidism.

    • Implications:

    • This case represents a rare instance of hyperfunctioning differentiated thyroid carcinoma.
    • It underscores the importance of considering malignancy in young patients with seemingly benign hyperfunctioning nodules.
    • The co-occurrence of these conditions is exceptionally uncommon, offering insights into thyroid pathology.