[Effect of prostaglandin A1 on systemic and regional hemodynamics in dogs]

Intravenous administration of prostaglandin A1--PGA1 (10 gamma/kg) brings down arterial pressure, increases the rate of cardiac contractions, of cardiac output and myocardial contractility. Despite elevated pressure in the pulmonary artery the overall pulmonary resistance decreases without any substantial intensification of the right ventricle output. The mean circulation volume in the common carotid and superior mesenteric arteries shows but a momentary increase under the effect of PGA1. This is attended by a more significant and protracted rise of the circulation volume in the femoral and renal arteries, the maximum increase amounting to 140 and 39 per cent, respectively.