[Effect of pyrazidole on changes in blood sugar concentration caused by adrenaline and serotonin in intact and...

The effect produced by pyrazidol, a new tricyclic antidepressant, on changes in the blood sugar concentration caused by epinephrine and serotonin was investigated. Pyrazidol appreciably intensifies the effect of serotonin in intact and adrenalectomized animals. Under the influence of pyrazidol the action of epinephrine in intact animals also gains in strength, while in adrenalectomized animals pyrazidol lessens the hyperglycemic effect of epinephrine. Since the introduction of cortisol to adrenalectomized animals restores the effect of pyrazidol it is suggested that the influence of pyrazidol on the blood sugar concentration is accomplished with participation of glucocorticoids.