Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dilute down lethal: a new lethal mutation in Japanese quail

M Tsudzuki1, Y Nakane, A Wada

  • 1Department of Laboratory Animal Science, College of Agriculture, Osaka Prefecture University, Japan.

Experimental Animals
|January 1, 1997
PubMed
Summary

A new Japanese quail mutation, dilute down lethal (DDL), causes lighter down color and bent digits in chicks. This autosomal recessive mutation results in all DDL chicks dying within three days of hatching.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure.

Journal of the American College of Cardiology·2000
Same author

Mycobacterium kansaii flexor tenosynovitis presenting as carpal tunnel syndrome.

Journal of hand surgery (Edinburgh, Scotland)·2000
Same author

Adrenomedullin inhibits spontaneous and bradykinin-induced but not oxytocin- or prostaglandin F(2alpha)-induced periodic contraction of rat uterus.

British journal of pharmacology·2000
Same author

Insufficient secretion of atrial natriuretic peptide at acute phase of myocardial infarction.

Journal of applied physiology (Bethesda, Md. : 1985)·2000
Same author

Studies on ATPase(GTPase) intrinsic to E. coli ribosomes.

Journal of biochemistry·2000
Same author

Inhibition by neuroprotective drug NS-7 of nicotine-induced 22Na(+) influx, 45Ca(2+) influx and catecholamine secretion in adrenal chromaffin cells.

Brain research·2000

Area of Science:

  • Avian genetics
  • Developmental biology
  • Mutant analysis

Background:

  • Japanese quail (Coturnix japonica) are a valuable model organism in research.
  • Mutations provide insights into genetic control of development and physiology.
  • Understanding lethal mutations is crucial for genetic studies.

Purpose of the Study:

  • To characterize a newly identified mutation in Japanese quail.
  • To determine the inheritance pattern and phenotypic effects of the dilute down lethal (DDL) mutation.
  • To propose a gene symbol for this mutation.

Main Methods:

  • Phenotypic observation of neonatal plumage and physical abnormalities.
  • Analysis of chick mortality rates.
  • Genetic crosses to determine the mode of inheritance.

Related Experiment Videos

Main Results:

  • The dilute down lethal (DDL) mutation presents with lighter neonatal plumage and, in some cases, bent digits.
  • DDL mutant chicks exhibit 100% mortality within three days post-hatching.
  • Genetic analysis indicates the DDL mutation is controlled by an autosomal recessive gene.

Conclusions:

  • The DDL mutation represents a novel genetic defect in Japanese quail.
  • The mutation affects plumage coloration and digit development, leading to lethality.
  • The proposed gene symbol 'ddl' is suggested for this autosomal recessive mutation.