[Pharmacokinetics of sulfamonomethoxine and ite N-methylglucamine salt in rats]

Tests conducted with albino rats demonstrated that after intramuscular administration of N-methylglucaminic salt of sulphamonomethoxine there are built up higher concentrations of the compound in the blood and organs than with its enteral introduction. The maximal sulphamonomethoxine concentrations in rats with the compound administered by mouth are observed in 3-6 hours and with its intramuscular injection--over a space of 30 minutes-1 hour. Doubling the dose of injectable sulphamonomethoxine resulted in a higher content of the compound in the organism of rats by comparison with its administration by mouth.