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Congenital ocular aberrant innervation--new concepts
1University of Washington School of Medicine, Redmond, USA.
Journal of Pediatric Ophthalmology and Strabismus
|January 1, 1997
Summary
Congenital aberrant innervations, often involving the sixth nerve, present in various forms. This study highlights unusual miswirings and proposes a unifying hypothesis for their occurrence.
Area of Science:
- Ophthalmology
- Neuroscience
- Pediatric Neurology
Background:
- Congenital aberrant innervations are ocular miswiring conditions.
- These conditions are more common than previously thought and often involve the sixth cranial nerve.
- Common examples include Duane's syndrome and Marcus Gunn jaw-winking ptosis.
Observation:
- This study observed unusual varieties of congenital aberrant innervations.
- These miswirings involve simultaneous activation of the lateral rectus with other muscles.
- Examples include pseudo inferior oblique overaction and synergistic divergence.
Findings:
- Aberrant innervations can involve the ipsilateral superior rectus, contralateral lateral rectus, or masticatory muscles.
- The third nerve is rarely involved in congenital miswiring but shows aberrant regeneration after injury.
- No cases of aberrant innervation involving the fourth nerve were identified.
Implications:
- Understanding these aberrant innervations is crucial for accurate diagnosis and treatment.
- Misdiagnosis can lead to ineffective surgical interventions.
- Further research into the unifying hypothesis regarding sixth nerve involvement is warranted.