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Diversity and evolution of the DRB1*03 family: description of DRB1*03022,*0307,*0308
1Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, District of Columbia, USA.
Tissue Antigens
|January 1, 1997
Abstract:
Three previously unreported DRB1*03 alleles are described, adding to the diversity of the DRB1 family of alleles. DRB1*03022 contains a silent substitution at codon 77. DRB1*0307 differs from DRB1*03011 by a substitution at codon 26 resulting in a predicted change from tyrosine to phenylalanine. DRB1*0308 is almost identical to DRB1*03011 differing at codon 58 which specifies the glutamic acid residue commonly found in DRB1*11 alleles. The new alleles (DRB1*03022,*0307,*0308) may have arisen by gene conversion-like events and add to the increasing complexity of the HLA system.