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Protection by trehalose of DNA from radiation damage
K Yoshinaga1, H Yoshioka, H Kurosaki
1Department of Chemistry, Faculty of Science, Shizuoka University, Japan.
Bioscience, Biotechnology, and Biochemistry
|January 1, 1997
Abstract:
The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mM trehalose, DNA can be protected from about 4 times higher doses of beta- and gamma-ray irradiation. The protective effect increases with the amount of the sugar. Other disaccharides, sucrose, and maltose had similar effects.