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Isolation and identification of alpha-glucosidase inhibitors from tochu-cha (Eucommia ulmoides)
J Watanabe1, J Kawabata, H Kurihara
1Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan.
Bioscience, Biotechnology, and Biochemistry
|January 1, 1997
Abstract:
alpha-Glucosidase inhibitory activity was found in aqueous methanol extracts of tochu-cha, dried leaves of Eucommia ulmoides (Eucommiaceae). Five active principles against yeast enzyme were isolated and characterized. Among them, quercetin (1, Ki: 8.5 x 10(-6) M) was considered to contribute mostly to the activity of the tochu leaves. In regard to an animal alpha-glucosidase, rat intestinal sucrase activity was also inhibited by 1.