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[Chronic myelogenous leukemia expressing two bcr-abl chimeric mRNA; a case report]
S Hashimoto1, M Hiyoshi, M Hino
1Department of Clinical Hematology, Osaka City University Medical School.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|January 1, 1997
Summary
This study reports a rare case of chronic myelogenous leukemia (CML) with dual bcr-abl mRNA expression. This dual expression may offer a novel method for monitoring CML progression.
Area of Science:
- Hematology
- Molecular Biology
- Oncology
Background:
- Chronic myelogenous leukemia (CML) is characterized by the BCR-ABL fusion gene.
- BCR-ABL can form different chimeric mRNA transcripts, including b3a2 and b2a2 types.
- Co-expression of multiple BCR-ABL transcripts is uncommon in CML patients.