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Is TNF really involved in cachexia?
C García-Martínez1, P Costelli, F J López-Soriano
1Department of Biochemistry and Physiology, Facultat de Biologia, Universitat de Barcelona, Spain.
Cancer Investigation
|January 1, 1997
Abstract:
A review on the possible involvement of tumor necrosis factor-alpha (TNF) in cachexia is presented. While this cytokine is definitely linked to sepsis and tumor-associated weight loss in some experimental models, other cytokines, such as interleukin-6 (IL-6) or interferon-gamma (IFN-gamma), alone or in combination with TNF, may also play an important role in the development of cachexia.